Alteration in the relationship between tanycytes and gonadotrophin-releasing hormone neurosecretory terminals following long-term metabolic manipulation in the sheep
R Pouchain Ribeiro Neto, IJ Clarke, G Conductier
JOURNAL OF NEUROENDOCRINOLOGY | WILEY | Published : 2017
The activity of the hypothalamic-pituitary gonadal axis is influenced by energy reserves, such that an increase or a decrease in adiposity may perturb the secretion and action of gonadotrophin-releasing hormone (GnRH). This is considered to be a result of the signalling of hormones such as leptin, which act upon neuronal systems controlling GnRH secretion. Other work shows plasticity in the relationship between tanycytes and GnRH neurosecretory terminals in the median eminence across the oestrous cycle and we hypothesised that a similar plasticity may occur with altered metabolic status. We studied Lean, Normal and Fat ovariectomised ewes, which displayed differences in gonadotrophin status,..View full abstract
Work in the laboratories of the authors is supported by funding from the National Health and Medical Research Council of Australia (NHMRC), the Australian Research Council (ARC) and the Diabetes Australia Research Trust. GS is supported by a University Postgraduate Award and AFS is supported by an Australian Research Training Program Scholarship.