Journal article

Glucocorticoid treatment facilitates development of a metabolic syndrome in ovariectomized Macaca Mulatta fed a high fat diet

Linzhao Li, Guang Yang, Guangneng Liao, Jie Mei, Lan Li, Chengshi Wang, Yujia Yuan, Yujun Shi, Jingping Liu, Zhihui Zhong, Jingqiu Cheng, Yanrong Lu, Iain J Clarke, Younan Chen

STEROIDS | ELSEVIER SCIENCE INC | Published : 2017

Abstract

Metabolic syndrome (MetS) is characterized by a cluster of key features, which include abdominal obesity, insulin resistance, hypertension, and dyslipidemia. The aim of this study was to assess the impact of elevated glucocorticoid levels on the development of MetS in middle-aged female rhesus monkeys (Macaca Mulatta) after ovariectomy. Six female ovariectomized rhesus monkeys (9-13years) were randomly assigned to either a control group (normal diet, n=3) or a group in which MetS was facilitated (n=3). The MetS group fed with HFD (15% fat) and received oral prednisone acetate treatment (50mg/day). After 24months, the GCs treatment was withdrawn with continuation of high-fat feeding for a fur..

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University of Melbourne Researchers

Grants

Awarded by National Basic Research Program of China (973 program)


Awarded by Program of National Natural Science Foundation of China


Awarded by National Program for High Technology Research and Development of China


Funding Acknowledgements

This study was supported by the National Basic Research Program of China (973 program) (2013CB530702), the Program of National Natural Science Foundation of China (81000351), National Program for High Technology Research and Development of China (No. 2012AA020702) and the National Key Clinical Project.