Glucocorticoid treatment facilitates development of a metabolic syndrome in ovariectomized Macaca Mulatta fed a high fat diet
Linzhao Li, Guang Yang, Guangneng Liao, Jie Mei, Lan Li, Chengshi Wang, Yujia Yuan, Yujun Shi, Jingping Liu, Zhihui Zhong, Jingqiu Cheng, Yanrong Lu, Iain J Clarke, Younan Chen
STEROIDS | ELSEVIER SCIENCE INC | Published : 2017
Metabolic syndrome (MetS) is characterized by a cluster of key features, which include abdominal obesity, insulin resistance, hypertension, and dyslipidemia. The aim of this study was to assess the impact of elevated glucocorticoid levels on the development of MetS in middle-aged female rhesus monkeys (Macaca Mulatta) after ovariectomy. Six female ovariectomized rhesus monkeys (9-13years) were randomly assigned to either a control group (normal diet, n=3) or a group in which MetS was facilitated (n=3). The MetS group fed with HFD (15% fat) and received oral prednisone acetate treatment (50mg/day). After 24months, the GCs treatment was withdrawn with continuation of high-fat feeding for a fur..View full abstract
Awarded by National Basic Research Program of China (973 program)
Awarded by Program of National Natural Science Foundation of China
Awarded by National Program for High Technology Research and Development of China
This study was supported by the National Basic Research Program of China (973 program) (2013CB530702), the Program of National Natural Science Foundation of China (81000351), National Program for High Technology Research and Development of China (No. 2012AA020702) and the National Key Clinical Project.