Journal article

Is centrally induced alveolar bone loss in a large animal model preventable by peripheral hormone substitution?

Maciej JK Simon, Frank Timo Beil, Pia Pogoda, Eik Vettorazzi, Iain Clarke, Michael Amling, Ralf Oheim

CLINICAL ORAL INVESTIGATIONS | SPRINGER HEIDELBERG | Published : 2018

Abstract

OBJECTIVES: Alveolar bone structures are mostly investigated in small animal models. The majority of these studies examined local influences on the alveolar bone, but only a few examined systemic influencing factors. The hypothalamic-pituitary axis is known to be essential for a vital bone balance. The aim of this study was to analyse the effects that selective hormone treatments have on alveolar bone structure and quality in a sheep model for alveolar bone loss, induced by hypothalamic-pituitary disconnection (HPD). METHODS: Thirty sheep were randomly selected into six groups of five each: control (C), ovariectomy-OVX (O), O + HPD (OH), OH with oestrogen treatment (OHE), OH with thyroxine (..

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University of Melbourne Researchers