Is centrally induced alveolar bone loss in a large animal model preventable by peripheral hormone substitution?
Maciej JK Simon, Frank Timo Beil, Pia Pogoda, Eik Vettorazzi, Iain Clarke, Michael Amling, Ralf Oheim
CLINICAL ORAL INVESTIGATIONS | SPRINGER HEIDELBERG | Published : 2018
OBJECTIVES: Alveolar bone structures are mostly investigated in small animal models. The majority of these studies examined local influences on the alveolar bone, but only a few examined systemic influencing factors. The hypothalamic-pituitary axis is known to be essential for a vital bone balance. The aim of this study was to analyse the effects that selective hormone treatments have on alveolar bone structure and quality in a sheep model for alveolar bone loss, induced by hypothalamic-pituitary disconnection (HPD). METHODS: Thirty sheep were randomly selected into six groups of five each: control (C), ovariectomy-OVX (O), O + HPD (OH), OH with oestrogen treatment (OHE), OH with thyroxine (..View full abstract
Awarded by German Research Foundation
This work was supported by the German Research Foundation (DFG) within the framework of the DFG Research Group 793 to PP and MA. FTB, MJKS, and RO are fellows of the German Research Foundation (DFG AM 103/13-1 and DFG AM 103/14-1).