Differences in mitochondrial DNA inheritance and function align with body conformation in genetically lean and fat sheep
BA Henry, R Loughnan, J Hickford, IR Young, JC St John, I Clarke
JOURNAL OF ANIMAL SCIENCE | OXFORD UNIV PRESS INC | Published : 2015
Body weight and adiposity are determined by the balance between energy intake, energy expenditure, and nutrient deposition. We have identified differences in appetite-regulating peptides in sheep selectively bred to be either lean or fat, wherein gene expression for orexin and melanin-concentrating hormone are elevated in the lean group. Despite this, the underlying mechanisms leading to differences in body composition in the lean and fat lines remains unknown. We measured postprandial temperature in adipose tissue and muscle to ascertain whether a difference in thermogenesis is associated with the difference in body composition in genetically lean (n = 8) and fat (n = 12) ewes. Body weight ..View full abstract
Awarded by National Health and Medical Research Council of Australia
The authors thank Bruce Doughton, Elaine Chase, Nigel Jay, Martin Wellby, and Martin Ridgway for animal husbandry and assistance with animal work. This work was supported by a grant from the National Health and Medical Research Council of Australia (number 1005935).