Journal article

Kisspeptin and Seasonality of Reproduction

Iain J Clarke, Alain Caraty, AS Kauffman (ed.), JT Smith (ed.)

Advances in Experimental Medicine and Biology | SPRINGER | Published : 2013


Wild and domesticated species display seasonality in reproductive function, controlled predominantly by photoperiod. Seasonal alterations in breeding status are caused by changes in the secretion of gonadotropin-releasing hormone (GnRH) that are mediated by upstream neuronal afferents that regulate the GnRH cells. In particular, kisspeptin appears to play a major role in seasonality of reproduction, transducing the feedback effect of gonadal steroids as well as having an independent (nonsteroid dependent) circannual rhythm. A substantial body of data on this issue has been obtained from studies in sheep and hamsters and this is reviewed here in detail. Kisspeptin function is upregulated duri..

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University of Melbourne Researchers