Paradoxical Effect of Gonadotrophin-Inhibiting Hormone to Negatively Regulate Neuropeptide Y Neurones in Mouse Arcuate Nucleus
JS Jacobi, HA Coleman, PJ Enriori, HC Parkington, Q Li, A Pereira, MA Cowley, IJ Clarke
JOURNAL OF NEUROENDOCRINOLOGY | WILEY-BLACKWELL | Published : 2013
Regulation of reproduction and energy homeostasis are linked, although our understanding of the central neural mechanisms subserving this connection is incomplete. Gonadotrophin-inhibiting hormone (GnIH) is a neuropeptide that negatively regulates reproduction and stimulates food intake. Neuropeptide Y (NPY) and products of the pro-opiomelanocortin (POMC) precursor (β-endorphin melanocortins) are appetite regulating peptides produced in the neurones of the arcuate nucleus; these peptides also regulate reproduction. In the present study, we determined the effects of GnIH on NPY and POMC neurones. Using brain slices from mice with transgenes for fluorescent tags in the two types of neurone and..View full abstract
We thank Adnan Sali and Joanne Pagnon for their technical assistance. This work was supported by the National Health and Medical Research Council of Australia. J.S.J received a Fellowship from the National Council of Science and Technology of Mexico (CONACYT).