Targeting the lateral but not the third ventricle induces bone loss in ewe: An experimental approach to generate an improved large animal model of osteoporosis
Ralf Oheim, Frank Timo Beil, Florian Barvencik, Marcus Egermann, Michael Amling, Iain J Clarke, Pia Pogoda
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
BACKGROUND: Osteoporosis is a chronic disease characterized by bone loss and increased skeletal fragility. Large animal models are required for preclinical testing of new therapeutic approaches. We have recently demonstrated that continuous intracerebroventricular (ICV) application of leptin into the lateral ventricle (LV) induces bone loss in ewe. On the basis of these findings, we reasoned that the third ventricle (TV) is an even better target because of its closer location to the hypothalamus that mediates leptin effects on bone. METHODS: Corriedale sheep were randomly mixed to four groups of four ewe each: control entire (control), ovarectomy plus ICV application of cerebrospinal fluid (..View full abstract
Awarded by AO Foundation
Awarded by German Research Community (DFG)
Supported by grants from the AO Foundation (AO 01-A58 to M.A. and P.P.) and the German Research Community (DFG Am 103-12/5 to M.A. and P.P.) in the framework of the transregional research group 793.