Journal article

Cells of the arcuate nucleus and ventromedial nucleus of the ovariectomized ewe that respond to oestrogen: A study using Fos immunohistochemistry

IJ Clarke, S Pompolo, CJ Scott, JA Rawson, D Caddy, AE Jakubowska, AM Pereira

JOURNAL OF NEUROENDOCRINOLOGY | BLACKWELL SCIENCE LTD | Published : 2001

Abstract

Oestrogen produces a positive feedback effect on the secretion of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) when implanted into the ventromedial/arcuate nucleus of the ovariectomized (OVX) ewe. This has led to the belief that it is in this area of the hypothalamus that oestrogen causes the preovulatory surge in GnRH/LH. To date, however, the cell types that are integral to this response have not been identified. The present study aimed to examine cellular responsiveness to oestrogen in this region of the brain using Fos immunohistochemistry and further aimed to determine the cell type that shows an acute response to oestrogen. OVX ewes (n = 4-6 per group) were given ..

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