Citalopram (antidepressant) administration causes sexual dysfunction in male mice through RF-amide related peptide in the dorsomedial hypothalamus
Tomoko Soga, Dutt Way Wong, Iain J Clarke, Ishwar S Parhar
NEUROPHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2010
Citalopram is the most potent selective serotonin reuptake inhibitor (SSRI) which is used as an antidepressant but causes sexual dysfunction. Whether citalopram induced sexual dysfunction is a result of gonadotropin-releasing hormone (GnRH), kisspeptin or RF-amide related peptide (RFRP) alteration is unknown. In this study, we tested mice for sexual behavior after vehicle (0.9% NaCl) and citalopram treatment (5 mg/kg) daily for 1 day (acute) and 21 or 28 days (chronic). Effects of acute and chronic treatments on neuronal numbers and mRNA expression of GnRH, kisspeptin and RFRP were measured. In addition, RFRP fiber projections to preoptic (POA)-GnRH neurons were analyzed using double-label i..View full abstract
Awarded by Monash University
This work was supported by research grants from Monash University Sunway Campus, MM-2-3-06 (T.S) and MM-2-5-06 (I.S.P).