Sex Differences in the Metabolic Effects of Testosterone in Sheep
Scott D Clarke, Iain J Clarke, Alexandra Rao, Michael A Cowley, Belinda A Henry
ENDOCRINOLOGY | ENDOCRINE SOC | Published : 2012
Adiposity is regulated in a sexually divergent manner. This is partly due to sex steroids, but the differential effects of androgens in males and females are unclear. We investigated effects of testosterone on energy balance in castrated male (n = 6) and female sheep (n = 4), which received 3 × 200 mg testosterone implants for 2 wk or blank implants (controls). Temperature probes were implanted into retroperitoneal fat and skeletal muscle. Blood samples were taken to measure metabolites and insulin. In males, muscle and fat biopsies were collected to measure uncoupling protein (UCP) mRNA and phosphorylation of AMP-activated protein kinase and Akt. Testosterone did not change food intake in e..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by National Health and Medical Research Council of Australia Grant 1005935.