Journal article

Noninvasive Analytical Estimation of Endogenous GnRH Drive: Analysis Using Graded Competitive GnRH-Receptor Antagonism and a Calibrating Pulse of Exogenous GnRH

Daniel M Keenan, Iain J Clarke, Johannes D Veldhuis

ENDOCRINOLOGY | ENDOCRINE SOC | Published : 2011

Abstract

Homeostatic control of endocrine systems proceeds via feedforward (agonistic, stimulatory) and feedback (antagonistic, inhibitory) interactions mediated via implicit dose-response functions. However, neither the feedback/feedforward pathways nor the dose-response interfaces are directly observed in vivo. Thus, the goal was to formulate and estimate an ensemble construct of time-varying feedback/feedforward interactions among GnRH, LH, and testosterone (T) in the male gonadal axis. The new analytical model revises and extends an earlier construct by: 1) allowing systemic T concentrations to inhibit hypothalamic GnRH output; 2) estimating GnRH outflow after injection of a calibrating pulse of ..

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University of Melbourne Researchers

Grants

Awarded by National Center for Research Resources via the Center for Translational Science Activities


Awarded by National Institutes of Health (Metabolic Studies Core of the Minnesota Obesity Center)


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

This work was supported in part by the National Center for Research Resources Grant 1 UL 1 RR024150 via the Center for Translational Science Activities and by National Institutes of Health Grants R01 AG023777, R01 AG031763, and DK50456 (Metabolic Studies Core of the Minnesota Obesity Center).