Journal article
Noninvasive analytical estimation of endogenous GnRH drive: Analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH
DM Keenan, IJ Clarke, JD Veldhuis
Endocrinology | ENDOCRINE SOC | Published : 2011
DOI: 10.1210/en.2011-1461
Abstract
Homeostatic control of endocrine systems proceeds via feedforward (agonistic, stimulatory) and feedback (antagonistic, inhibitory) interactions mediated via implicit dose-response functions. However, neither the feedback/feedforward pathways nor the dose-response interfaces are directly observed in vivo. Thus, the goal was to formulate and estimate an ensemble construct of time-varying feedback/feedforward interactions among GnRH, LH, and testosterone (T) in the male gonadal axis. The new analytical model revises and extends an earlier construct by: 1) allowing systemic T concentrations to inhibit hypothalamic GnRH output; 2) estimating GnRH outflow after injection of a calibrating pulse of ..
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Awarded by National Institute on Aging
Funding Acknowledgements
This work was supported in part by the National Center for Research Resources Grant 1 UL 1 RR024150 via the Center for Translational Science Activities and by National Institutes of Health Grants R01 AG023777, R01 AG031763, and DK50456 (Metabolic Studies Core of the Minnesota Obesity Center).