Journal article

REGULATION OF FOLLICLE-STIMULATING HORMONE-BETA AND COMMON ALPHA-SUBUNIT MESSENGER RIBONUCLEIC-ACID BY GONADOTROPIN-RELEASING HORMONE AND ESTROGEN IN THE SHEEP PITUITARY

JE MERCER, JA CLEMENTS, JW FUNDER, IJ CLARKE

Neuroendocrinology | KARGER | Published : 1989

Abstract

The effect of gonadotropin-releasing hormone (GnRH) and/or estradiol (E2) on pituitary messenger ribonucleic acid (mRNA) levels of luteinizing hormone beta (LH beta), follicle-stimulating hormone beta (FSH beta) and the common alpha-subunit were determined in anterior pituitary glands from ovariectomized (OVX) ewes. Hypothalamo-pituitary disconnected (HPD) ewes receiving appropriate hormonal treatment were used to assess the relative roles of GnRH and E2 in directly regulating FSH beta and alpha-subunit mRNA levels. Levels of LH beta mRNA were increased in OVX animals compared with intact controls, and E2 treatment of OVX animals significantly reduced mRNA levels of LH beta and FSH beta. HPD..

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