Journal article

ADRENOCORTICOTROPIN RESPONSES TO ENDOGENOUS AND EXOGENOUS SECRETAGOGUES IN THE SHEEP - SPECIFICITY OF GLUCOCORTICOID ACTION

BJ CANNY, IJ CLARKE, JW FUNDER

NEUROENDOCRINOLOGY | KARGER | Published : 1990

Abstract

Glucocorticoids act upon the hypothalamus and pituitary to regulate both corticotropin-releasing factors and adrenocorticotropin (ACTH) in a classical negative feedback loop. There are two distinct receptor systems in the central nervous system for glucocorticoids: type I corticosterone/cortisol-preferring, predominantly hippocampal receptors, and type II dexamethasone-binding receptors with a much broader distribution. To determine the relative roles played by these two receptors in determining basal and stress-induced ACTH/cortisol levels in the sheep, we have conducted two series of experiments. In the first, we infused 4 sheep with cortisol (50 micrograms/h), or dexamethasone (20 microgr..

View full abstract

University of Melbourne Researchers