Journal article

Two decades of measuring GnRH secretion

IJ Clarke



It is almost 20 years since it was first demonstrated that serial hypophysial portal blood samples could be obtained from conscious sheep and, subsequently, from cattle, goats and pigs. Accumulated data have defined the patterns of secretion of GnRH in the normal physiological state and the effects of gonadal steroids have also been largely defined. In particular, changes across the oestrous cycle of females have been studied in detail. These data show that there is an increase in the frequency of pulsatile discharges of GnRH in the transition from the luteal to the follicular phase of the oestrous cycle, with an inverse change in the amplitude of GnRH pulses; such changes are reflected in t..

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University of Melbourne Researchers