Random and Non‐Random Coincidence Between Luteinizing Hormone Peaks and Follicle‐Stimulating Hormone, Alpha Subunit, Prolactin and Gonadotropin‐Releasing Hormone ulsations

Abstract

We have examined the co‐pulsatility of luteinizing hormone (LH) and prolactin, LH and follicle‐stimulating hormone (FSH), and LH and α subunit in normal men. We tested whether the degree of physiologically observed co‐pulsatility (peak coincidence) significantly exceeded expected random concordance between independently pulsating hormone series. To this end, computer simulations were used to create synthetic endocrine time series pulsating randomly and independently at known frequencies. Resultant predictions of the mean, variance and probability distribution of the number of randomly coincident peaks permitted us to test the null hypothesis that physiologically observed hormone co‐pulsatili..