Effects of estrogen and estrous cycle on glucocorticoid and catecholamine responses to stress in sheep.
PA Komesaroff, M Esler, IJ Clarke, MJ Fullerton, JW Funder
Am J Physiol | Published : 1998
There have been relatively few studies of the effects of estrogen on hormonal responses to stress. We therefore studied changes in ACTH, cortisol, norepinephrine (NE), and epinephrine (Epi) after stress induced by a barking dog (audiovisual stressor) and insulin-induced hypoglycemia (metabolic stressor) in ovariectomized sheep treated with estradiol or placebo and in intact sheep in the follicular and luteal phases of the estrous cycle. Both stressors produced acute increases in ACTH, cortisol, Epi, and NE. A high physiological dose of estradiol significantly reduced the ACTH and cortisol responses to both stressors but did not affect Epi and NE responses. Plasma ACTH and cortisol responses ..View full abstract