Journal article

SOMATOSTATIN SECRETION AND ACTION IN THE REGULATION OF GROWTH-HORMONE SECRETION

LA FROHMAN, TR DOWNS, M KELIJMAN, IJ CLARKE, G THOMAS

METABOLISM-CLINICAL AND EXPERIMENTAL | W B SAUNDERS CO | Published : 1990

Abstract

The inhibition of growth hormone (GH) secretion by the hypothalamic peptide, somatostatin, is mediated by two critical factors: the concentration of the peptide in hypothalamic portal plasma and the number of somatostatin (SRIF) receptors on the somatotroph. The secretory patterns of SRIF and GH-releasing hormone (GRH) in portal blood of unanesthetized sheep is pulsatile and a close relationship of GRH pulses to those of GH secretion was documented, while those of SRIF appear to have more of a modulatory role on the responses to GRH. Peripheral infusion of SRIF at a rate to provide concentrations comparable to those in the portal system leads to a desensitization of SRIF effects on the somat..

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