Journal article

EVIDENCE FOR AN ULTRADIAN SECRETION OF ADRENOCORTICOTROPIN, BETA-ENDORPHIN AND ALPHA-MELANOCYTE-STIMULATING HORMONE BY THE OVINE ANTERIOR AND INTERMEDIATE PITUITARY

D ENGLER, T PHAM, MJ FULLERTON, IJ CLARKE, JW FUNDER

NEUROENDOCRINOLOGY | KARGER | Published : 1989

Abstract

These studies were undertaken to characterize the secretion of the pro-opiomelanocortin (POMC)-peptides adrenocorticotropin (ACTH), immunoreactive (ir)-beta-endorphin (beta-EP), and ir-alpha-melanocyte-stimulating hormone (ir-alpha-MSH) in the conscious sheep. When blood samples were taken at 10-min intervals, a distinct POMC-peptide and cortisol ultradian rhythm was observed, and 4 of the 7 possible POMC-peptide pulse patterns were defined. Three of these patterns included pulsatile ACTH secretion, and 70% were followed by a rise in plasma cortisol. The fourth pulse pattern consisted of concordant ir-beta-EP and ir-alpha-MSH secretion and was not temporally correlated with cortisol secretio..

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