Journal article

SHORT-TERM REGULATION OF GONADOTROPIN SUBUNIT MESSENGER-RNA LEVELS BY ESTROGEN - STUDIES IN THE HYPOTHALAMOPITUITARY INTACT AND HYPOTHALAMOPITUITARY DISCONNECTED EWE

JE MERCER, DJ PHILLIPS, IJ CLARKE

JOURNAL OF NEUROENDOCRINOLOGY | BLACKWELL SCIENCE LTD | Published : 1993

Abstract

In this study the levels of mRNA for the pituitary gonadotropin hormone subunits luteinizing hormone beta (LHbeta), follicle stimulating hormone beta (FSHbeta) and the common alpha-subunit were assessed during the acute feedback stages of estradiol benzoate (EB) action in ovariectomized (OVX) ewes with and without hypothalamo-pituitary disconnection (HPD). In OVX/HPD ewes maintained on hourly pulses of 250 micrograms of gonadotropin-releasing hormone (GnRH) a single i.m. injection of EB in oil caused a biphasic (decrease and then increase) change in plasma LH levels and a monophasic decrease in FSH levels. There was a decrease in pituitary alpha-subunit and FSHbeta mRNA levels during the acu..

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