Journal article

NEGATIVE FEEDBACK-REGULATION OF THE SECRETION AND ACTIONS OF GNRH IN MALE RUMINANTS

AJ TILBROOK, IJ CLARKE

JOURNAL OF REPRODUCTION AND FERTILITY | J REPROD FERTIL INC | Published : 1995

Abstract

The roles of testicular hormones in the negative feedback regulation of the secretion and actions of GnRH in male domestic ruminants are reviewed, concentrating mainly on research conducted with rams. Testicular steroids have major feedback actions directly at the hypothalamus to inhibit the secretion of GnRH, although it is apparent that, under certain circumstances, the steroids also have actions directly at the pituitary gland. Further research is necessary to delineate these actions and to determine the contribution of testosterone and its primary metabolites, dihydrotestosterone and oestradiol, to negative feedback on the hypothalamo-pituitary unit. Since GnRH neurones do not possess re..

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University of Melbourne Researchers