Journal article

Leptin inhibits bone formation not only in rodents, but also in sheep

Pia Pogoda, Marcus Egermann, Johann C Schnell, Matthias Priemel, Arndt F Schilling, Mauro Alini, Thorsten Schinke, Johannes M Rueger, Erich Schneider, Lain Clarke, Michael Amling

JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 2006

Abstract

UNLABELLED: This study examines the effect of long-term ICV administration of leptin in ewes. We found that central application significantly decreased osteoblast activity as measured by serum analysis as well as by histomorphometry, resulting in decreased trabecular bone volume. These data provide additional evidence that bone formation and therefore bone remodeling is at least in part centrally controlled. INTRODUCTION: Genetic studies in mice have identified leptin as a potent inhibitor of bone formation acting through the central nervous system and unraveled the central nature of bone mass control and its disorders. Although these studies have radically enhanced our understanding of skel..

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