Journal article

PHARMACODYNAMICS OF GONADOTROPIN-RELEASING HORMONE .1. EFFECTS OF GONADOTROPIN-RELEASING HORMONE PULSE CONTOUR ON PITUITARY LUTEINIZING-HORMONE SECRETION INVIVO IN SHEEP

DJ HANDELSMAN, JT CUMMINS, IJ CLARKE

NEUROENDOCRINOLOGY | KARGER | Published : 1988

Abstract

The gonadotropin-releasing hormone (GnRH) waveform arrives at the pituitary gonadotropes via the pituitary portal blood and provides the immediate suprapituitary stimulus to luteinizing hormone (LH) secretion. Despite their importance, nature and influence of the physiological GnRH waveform in vivo have been difficult to study. Recent pharmacological and in vitro studies have suggested the potential importance of the wave contour as a specific and independent factor in the pharmacodynamic effects of GnRH on pituitary gonadotrope LH secretion in vivo, and it has been hypothesized that the steepness of the rising edge of the GnRH wave contour is a specific determinant of pituitary LH secretion..

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