Conference Proceedings

Gonadal steroid receptors in the regulation of GnRH secretion in farm animals

CJ Scott, AJ Tilbrook, JA Rawson, IJ Clarke

ANIMAL REPRODUCTION SCIENCE | ELSEVIER SCIENCE BV | Published : 2000

Abstract

The sites of action and mechanisms by which gonadal steroids regulate gonadotrophin-releasing hormone (GnRH) in domestic animals remain largely unknown. This review summarises information gained from sheep regarding the distribution of the gonadal steroid receptors in the brain, the neurochemical identity and the projections of these steroid receptor-containing neurones. The cells in the hypothalamus that contain each of the gonadal steroid receptors (oestrogen receptor alpha (ERalpha), oestrogen receptor beta (ERbeta), progesterone receptor (PR) and androgen receptor (AR)) show a remarkably similar distribution, although the PR and AR-containing cells are less widespread than oestrogen rece..

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University of Melbourne Researchers