Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep: I. effect of an audiovisual stimulus and insulin-induced hypoglycemia

Abstract

Studies were undertaken to characterize the secretion of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) into the hypophysial-portal circulation ofthe conscious sheep. In addition, we examined the temporal relationship between the secretion of these two hypothalamic peptides and the secretion of three proopiomelanocortin peptides - adrenocorticotropic hormone (ACTH), ir-β-endorphin, and ir-αmelanocyte-stimtilaiing hormone - and Cortisol and determined the effects of an audiovisual emotional stimulus and insulin-induced hypoglycemia on the entire hypo-thalamic-pituitary-adrenal axis. In the basal state, the secretion of CRF. AVP, the three proopiomelanocortin peptides, and..