Journal article

Seasonal breeding as a neuroendocrine model for puberty in sheep

Jeremy T Smith, Lain J Clarke

MOLECULAR AND CELLULAR ENDOCRINOLOGY | ELSEVIER IRELAND LTD | Published : 2010

Abstract

Puberty is defined as the awakening of the hypothalamic-pituitary gonadal axis. Sheep are seasonal breeders, experiencing an annual period of reproductive quiescence and renaissance that can be utilized as a model for the onset of puberty. Kisspeptin and gonadotropin-inhibitory hormone appear to be important for the seasonal shift in reproductive activity and the former is mandatory for puberty. The non-breeding season is characterized by an increase in the negative feedback effect of estrogen on GnRH and gonadotropin secretion, as is the case in the pre-pubertal period. This effect of estrogen may be transmitted by kisspeptin cells. Additionally, dopaminergic A14/A15 neurons facilitate the ..

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University of Melbourne Researchers