Journal article

EFFECT OF LONG-TERM HYPOPHYSECTOMY ON OVARIAN FOLLICLE POPULATIONS AND GONADOTROPIN-INDUCED ADENOSINE CYCLIC 3',5'-MONOPHOSPHATE OUTPUT BY FOLLICLES FROM BOOROOLA EWES WITH OR WITHOUT THE F-GENE

KP MCNATTY, DA HEATH, N HUDSON, IJ CLARKE

JOURNAL OF REPRODUCTION AND FERTILITY | J REPROD FERTIL INC | Published : 1990

Abstract

Long-term (i.e. approximately 70 days) hypophysectomy led to a significant (P less than 0.05) reduction in ovarian weight but no reduction in the total number of antral follicles (greater than 0.1 mm in diameter). In hypophysectomized ++ Booroola ewes (N = 8) follicles were always less than or equal to 3 mm and in hypophysectomized FF Booroola ewes (N = 6) follicles were always less than or equal to 2 mm in diameter; in ewes of both genotypes follicles reached diameters which were approximately 40% of their predicted final size at ovulation. Under in-vitro conditions, follicles from the FF and ++ hypophysectomized ewes produced significant increases in cAMP within 1 h of exposure to gonadotr..

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