Mapping Alterations of the Functional Structure of the Cerebral Cortex in Obsessive-Compulsive Disorder
Jesus Pujol, Laura Blanco-Hinojo, Didac Macia, Pino Alonso, Ben J Harrison, Gerard Martinez-Vilavella, Joan Deus, Jose M Menchon, Narcis Cardoner, Carles Soriano-Mas
CEREBRAL CORTEX | OXFORD UNIV PRESS INC | Published : 2019
We mapped alterations of the functional structure of the cerebral cortex using a novel imaging approach in a sample of 160 obsessive-compulsive disorder (OCD) patients. Whole-brain functional connectivity maps were generated using multidistance measures of intracortical neural activity coupling defined within isodistant local areas. OCD patients demonstrated neural activity desynchronization within the orbitofrontal cortex and in primary somatosensory, auditory, visual, gustatory, and olfactory areas. Symptom severity was significantly associated with the degree of functional structure alteration in OCD-relevant brain regions. By means of a novel imaging perspective, we once again identified..View full abstract
Awarded by Carlos III Health Institute
Carlos III Health Institute (Grants PI13/01958 and PI16/00889).