Journal article

Mapping Alterations of the Functional Structure of the Cerebral Cortex in Obsessive-Compulsive Disorder

Jesus Pujol, Laura Blanco-Hinojo, Didac Macia, Pino Alonso, Ben J Harrison, Gerard Martinez-Vilavella, Joan Deus, Jose M Menchon, Narcis Cardoner, Carles Soriano-Mas

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2019


We mapped alterations of the functional structure of the cerebral cortex using a novel imaging approach in a sample of 160 obsessive-compulsive disorder (OCD) patients. Whole-brain functional connectivity maps were generated using multidistance measures of intracortical neural activity coupling defined within isodistant local areas. OCD patients demonstrated neural activity desynchronization within the orbitofrontal cortex and in primary somatosensory, auditory, visual, gustatory, and olfactory areas. Symptom severity was significantly associated with the degree of functional structure alteration in OCD-relevant brain regions. By means of a novel imaging perspective, we once again identified..

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University of Melbourne Researchers