Journal article

No evidence for a BRD2 promoter hypermethylation inblood leukocytes of Europeans with juvenile myoclonic epilepsy

Herbert Schulz, Ann-Kathrin Ruppert, Federico Zara, Francesca Madia, Michele Iacomino, Maria S Vari, Ganna Balagura, Carlo Minetti, Pasquale Striano, Amedeo Blanche, Carla Marini, Renzo Guerrini, Yvonne G Weber, Felicitas Becker, Holger Lerche, Claudia Kapser, Christoph J Schankin, Wolfram S Kunz, Rikke S Moller, Karen L Oliver Show all

Epilepsia | WILEY | Published : 2019

Abstract

Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Linkage and association studies suggest that the gene encoding the bromodomain-containing protein 2 (BRD2) may increase risk of JME. The present methylation and association study followed up a recent report highlighting that the BRD2 promoter CpG island (CpG76) is differentially hypermethylated in lymphoblastoid cells from Caucasian patients with JME compared to patients with other GGE subtypes and unaffected relatives. In contrast, we found a uniform low average percentage of methylation (<4.5%) for 13 CpG76-CpGs in whole blood cells from 782 unrelated European Caucasians, including 116 JME pati..

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Grants

Awarded by European Union: FP6 Integrated Project EPICURE


Awarded by FP7 DESIRE


Awarded by EPITARGET


Awarded by German Research Foundation (DFG): EUROCORES Program EuroEPINOMICS


Awarded by DFG


Awarded by German Federal Ministry of Education and Research: NGFNplus EMINet


Awarded by IntenC


Awarded by Scientific and Technological Research Council of Turkey: TUBITAK


Awarded by Bogazici University Research Fund


Funding Acknowledgements

European Union: FP6 Integrated Project EPICURE, grant LSHM-CT-2006-037315 to H.L., and T.S.; FP7 DESIRE, grant 602531 to C.M., R.G., and T.S.; EPITARGET, grant 602102 to A.J.B. and P.H. German Research Foundation (DFG): EUROCORES Program EuroEPINOMICS, grant SA434/5-1 to T.S.; DFG Research Unit FOR2715, grants SA434/6-1 to T.S., WE4896/3-1 and WE4896/4-1 to Y.G.W., LE1030/16-1 to H.L., and BE2078/5-1 to A.J.B. German Federal Ministry of Education and Research: NGFNplus EMINet, grants 01GS08120 to T.S., and 01GS08123 to H.L.; IntenC, grant TUR 09/I10 to T.S. Scientific and Technological Research Council of Turkey: TUBITAK grant 106S027 to H.C. Bogazici University Research Fund: grants 05HB104D, 06B107D, and 08HB104D to H.C. National Health and Medical Research Council (Australia): grant to S.A.M., S.F.B., K.L.O., I.E.S., and S.F.B. The Heinz Nixdorf Recall Study is supported by the Heinz Nixdorf Foundation (Germany), the German Ministry of Education and Science, and the DFG (grants SI236/8-1, SI236/9-1, and ER155/6-1).