The role of the copA copper efflux system in acinetobacter baumannii virulence

SF Alquethamy; M Khorvash; VG Pederick; JJ Whittall; JC Paton; IT Paulsen; KA Hassan; CA McDevitt; BA Eijkelkamp

Journal article

The role of the copA copper efflux system in acinetobacter baumannii virulence

SF Alquethamy, M Khorvash, VG Pederick, JJ Whittall, JC Paton, IT Paulsen, KA Hassan, CA McDevitt, BA Eijkelkamp

International Journal of Molecular Sciences | MDPI | Published : 2019

DOI: 10.3390/ijms20030575

Download PDF

Abstract

Acinetobacter baumannii has emerged as one of the leading causative agents of nosocomial infections. Due to its high level of intrinsic and adapted antibiotic resistance, treatment failure rates are high, which allows this opportunistic pathogen to thrive during infection in immune-compromised patients. A. baumannii can cause infections within a broad range of host niches, with pneumonia and bacteraemia being associated with the greatest levels of morbidity and mortality. Although its resistance to antibiotics is widely studied, our understanding of the mechanisms required for dealing with environmental stresses related to virulence and hospital persistence, such as copper toxicity, is limit..

View full abstract

University of Melbourne Researchers

Christopher McDevitt Author

Related Projects (3)

DEFINING THE ROLE OF ZINC AT THE HOST-PNEUMOCOCCAL INTERFACE

Streptococcus pneumoniae is the world’s foremost bacterial pathogen. In Australia, bacterial infections are responsible for more than 9000 d..

MOLECULAR INSIGHTS INTO BACTERIAL METAL ION HOMEOSTASIS AND TOXICITY

This project aims to measure bacterial cellular metal concentrations, elucidate mechanisms cells use to adapt to changing extracellular meta..

NEW MOLECULAR TOOLS TO STUDY THE MECHANISMS OF BACTERIAL METAL HOMEOSTASIS

This project aims to provide new insight into how metal ion uptake is regulated. It will precisely measure the cellular concentrations of me..

Grants

Awarded by University of Adelaide

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (Australia) through Project Grants 1080784 and 1122582 to C.A.M., Project Grant 1159752 to B.A.E., and Program Grant 1071659 to J.C.P. The work was also funded by the Australian Research Council (ARC) Discovery Project Grants DP150104515 and DP170102102 to J.C.P. and C.A.M. Work performed by K.A.H. and I.T.P. was supported by NHMRC Project Grant 1120298. B.A.E. is supported by the Channel 7 Children's Research Foundation (161203) and a University of Adelaide Beacon Research Fellowship. C.A.M. is an ARC Future Fellow (FT170100006).