The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence

Saleh F Alquethamy; Marjan Khorvash; Victoria G Pederick; Jonathan J Whittall; James C Paton; Ian T Paulsen; Karl A Hassan; Christopher A McDevitt; Bart A Eijkelkamp

Journal article

The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence

Saleh F Alquethamy, Marjan Khorvash, Victoria G Pederick, Jonathan J Whittall, James C Paton, Ian T Paulsen, Karl A Hassan, Christopher A McDevitt, Bart A Eijkelkamp

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2019

DOI: 10.3390/ijms20030575

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Abstract

Acinetobacter baumannii has emerged as one of the leading causative agents of nosocomial infections. Due to its high level of intrinsic and adapted antibiotic resistance, treatment failure rates are high, which allows this opportunistic pathogen to thrive during infection in immune-compromised patients. A. baumannii can cause infections within a broad range of host niches, with pneumonia and bacteraemia being associated with the greatest levels of morbidity and mortality. Although its resistance to antibiotics is widely studied, our understanding of the mechanisms required for dealing with environmental stresses related to virulence and hospital persistence, such as copper toxicity, is limit..

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University of Melbourne Researchers

Christopher McDevitt Author Microbiology and Immunology

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Awarded by National Health and Medical Research Council (Australia)

Awarded by Australian Research Council (ARC)

Awarded by NHMRC Project Grant

Awarded by Channel 7 Children's Research Foundation

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (Australia) through Project Grants 1080784 and 1122582 to C.A.M., Project Grant 1159752 to B.A.E., and Program Grant 1071659 to J.C.P. The work was also funded by the Australian Research Council (ARC) Discovery Project Grants DP150104515 and DP170102102 to J.C.P. and C.A.M. Work performed by K.A.H. and I.T.P. was supported by NHMRC Project Grant 1120298. B.A.E. is supported by the Channel 7 Children's Research Foundation (161203) and a University of Adelaide Beacon Research Fellowship. C.A.M. is an ARC Future Fellow (FT170100006).