The subfornical organ in sodium appetite: Recent insights
Sarah S Ch'ng, Andrew J Lawrence
NEUROPHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
To maintain sodium homeostasis, animals will readily seek and ingest salt when salt-depleted, even at concentrations that they typically find aversive when sodium replete. This innate behaviour is known as sodium (or salt) appetite. Salt appetite is subserved by a conserved brain network that senses sodium need and promotes the ingestion of salty substances when sodium-deficient. The subfornical organ (SFO) is a circumventricular organ that has diverse roles encompassing cardiovascular regulation, energy balance, immune responses, reproduction, and hydromineral balance. The SFO acts as a central sensor of sodium need and is essential for the generation of salt appetite. In this review, we di..View full abstract
Awarded by NHMRC
AJL is a Principal Research Fellow of the National Health and Medical Research Council (NHMRC, 1116930), supported by an NHMRC project grant on salt appetite (1141724). We acknowledge the Victorian State Government Operational Infrastructure Scheme.