Mycobacterium ulcerans Population Genomics To Inform on the Spread of Buruli Ulcer across Central Africa
Koen Vandelannoote, Delphin Mavinga Phanzu, Kapay Kibadi, Miriam Eddyani, Conor J Meehan, Kurt Jordaens, Herwig Leirs, Francoise Portaels, Timothy P Stinear, Simon R Harris, Bouke C de Jong
MSPHERE | AMER SOC MICROBIOLOGY | Published : 2019
Buruli ulcer is a neglected tropical disease of skin and subcutaneous tissue caused by infection with the pathogen Mycobacterium ulcerans Many critical issues for disease control, such as understanding the mode of transmission and identifying source reservoirs of M. ulcerans, are still largely unknown. Here, we used genomics to reconstruct in detail the evolutionary trajectory and dynamics of M. ulcerans populations at a central African scale and at smaller geographical village scales. Whole-genome sequencing (WGS) data were analyzed from 179 M. ulcerans strains isolated from all Buruli ulcer foci in the Democratic Republic of the Congo, The Republic of Congo, and Angola that have ever yield..View full abstract
Awarded by European Research Council-INTERRUPTB starting grant
This work was supported by the Wellcome Trust Sanger Institute, the Department of Economy, Science and Innovation of the Flemish Government, and the Stop Buruli Consortium supported by the UBS Optimus Foundation. K.V. was supported by a PhD grant of the Flemish Interuniversity Council, University Development Cooperation (Belgium). B.C.D.J. and C.J.M. were supported by the European Research Council-INTERRUPTB starting grant (nr. 311725). The computational resources used in this work were provided by the HPC core facility CalcUA and VSC (Flemish Supercomputer Center), funded by the University of Antwerp, the Hercules Foundation and the Flemish Government, Department EWI.