Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Matthew J Watt; Ashlee K Clark; Luke A Selth; Vanessa R Haynes; Natalie Lister; Richard Rebello; Laura H Porter; Birunthi Niranjan; Sarah T Whitby; Jennifer Lo; Cheng Huang; Ralf B Schittenhelm; Kimberley E Anderson; Luc Furic; Poornima R Wijayaratne; Maria Matzaris; Magdalene K Montgomery; Melissa Papargiris; Sam Norden; Maria Febbraio; Gail P Risbridger; Mark Frydenberg; Daniel K Nomura; Renea A Taylor

Journal article

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Matthew J Watt, Ashlee K Clark, Luke A Selth, Vanessa R Haynes, Natalie Lister, Richard Rebello, Laura H Porter, Birunthi Niranjan, Sarah T Whitby, Jennifer Lo, Cheng Huang, Ralf B Schittenhelm, Kimberley E Anderson, Luc Furic, Poornima R Wijayaratne, Maria Matzaris, Magdalene K Montgomery, Melissa Papargiris, Sam Norden, Maria Febbraio Show all

Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019

DOI: 10.1126/scitranslmed.aau5758

University of Melbourne Researchers

Luc Furic Author The Sir Peter MacCallum Department of Oncology

Matthew Watt Author Anatomy and Physiology

Gail Risbridger Author The Sir Peter MacCallum Department of Oncology

Magdalene Montgomery Author Anatomy and Physiology

Related Projects (2)

UNDERSTANDING MEDIATORS OF METABOLIC DISEASE

This research proposal will identify changes in liver-secreted proteins during the development of fatty liver, and in the transition from fa..

LIPID METABOLISM IN HEALTH AND DISEASE

Obesity is associated with type 2 diabetes, fatty liver disease, cardiovascular disease and cancer. These inter-related diseases reduce life..

Grants

Awarded by Prostate Cancer Foundation of Australia

Awarded by National Health and Medical Research Council of Australia

Awarded by Victorian Cancer Agency

Awarded by Department of Health and Human Services acting through the Victorian Cancer Agency

Funding Acknowledgements

This work was supported by the Prostate Cancer Foundation of Australia (ID: PCFA-NCG 3313, awarded to M.J.W. and R.A.T.) and the Diabetes Australia Research Trust (awarded to M.J.W.). M.J.W., M.K.M., L.A.S., and G.P.R. are supported by the National Health and Medical Research Council of Australia (APP1077703, APP1143224, APP1102752, and APP1121057), and R.A.T. is supported by the Victorian Cancer Agency (MCRF15023). L.F. is supported by the Department of Health and Human Services acting through the Victorian Cancer Agency (MCRF16007).