Journal article

A complex mosaic of enteroviruses shapes community-acquired hand, foot and mouth disease transmission and evolution within a single hospital

Joanna CA Cobbin, Philip N Britton, Rebecca Burrell, Deepali Thosar, Kierrtana Selvakumar, John-Sebastian Eden, Cheryl A Jones, Edward C Holmes



Human enteroviruses (EV) pose a major risk to public health. This is especially so in the Asia-Pacific region where increasing numbers of hand, foot and mouth disease (HFMD) cases and large outbreaks of severe neurological disease associated with EV-A71 have occurred. Despite their importance, key aspects of the emergence, epidemiology and evolution of EVs remain unclear, and most studies of EV evolution have focused on a limited number of genes. Here, we describe the genomic-scale evolution of EV-A viruses sampled from pediatric patients with mild disease attending a single hospital in western Sydney, Australia, over an 18-month period. This analysis revealed the presence of eight viral ser..

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Awarded by NHMRC

Awarded by NHMRC CRE grant

Awarded by ARC Australian Laureate Fellowship

Awarded by NHMRC Early Career Fellowship

Awarded by NHMRC Post Graduate Scholarship

Funding Acknowledgements

This work was supported by NHMRC grant GNT1103804 to E.H. and C.A.J., and NHMRC CRE grant GNT1102962 to E.H. and C.A.J. In addition, E.C.H. is supported by an ARC Australian Laureate Fellowship (FL170100022). P.N.B. is/has been supported by NHMRC Early Career Fellowship (GNT1145817), NHMRC Post Graduate Scholarship (GNT1074547), the Royal Australasian College of Physicians NHMRC Award for Excellence, and Norah Therese Hayes-Ratcliffe/Sydney Medical School Dean's Fellowship.