Journal article
Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone Mass
Aileen Bahl, Eija Pollanen, Khadeeja Ismail, Sarianna Sipila, Tuija M Mikkola, Eva Berglund, Carl Marten Lindqvist, Ann-Christine Syvanen, Taina Rantanen, Jaakko Kaprio, Vuokko Kovanen, Miina Ollikainen
TWIN RESEARCH AND HUMAN GENETICS | CAMBRIDGE UNIV PRESS | Published : 2015
DOI: 10.1017/thg.2015.82
Abstract
The loss of estrogen during menopause causes changes in the female body, with wide-ranging effects on health. Estrogen-containing hormone replacement therapy (HRT) leads to a relief of typical menopausal symptoms, benefits bone and muscle health, and is associated with tissue-specific gene expression profiles. As gene expression is controlled by epigenetic factors (including DNA methylation), many of which are environmentally sensitive, it is plausible that at least part of the HRT-associated gene expression is due to changes in DNA methylation profile. We investigated genome-wide DNA methylation and gene expression patterns of white blood cells (WBCs) and their associations with body compos..
View full abstractGrants
Awarded by Academy of Finland
Awarded by Finnish Ministry of Culture and Education
Awarded by EPITRAIN - Innovative techniques and models to understand epigenetic regulation in the pathogenesis of common diseases
Awarded by ENGAGE,- European Network for Genetic and Genomic Epidemiology
Awarded by Swedish Research Council
Awarded by Swedish Cancer Society
Awarded by Swedish Childhood Cancer Foundation
Awarded by Swedish Foundation for Strategic Research
Awarded by Academy of Finland (AKA)
Funding Acknowledgements
This study was supported by the Academy of Finland (M. O., grant number 251316 V. K., grant number 114310, J. K., grant numbers 265240 and 263278, T. R., grant number 69818), Finnish Ministry of Culture and Education (V. K., grant number 89/627/2008, T. R., grant number 120/722/2003), The Sigrid Juselius Foundation (M. O.); EPITRAIN - Innovative techniques and models to understand epigenetic regulation in the pathogenesis of common diseases (EPITRAIN - FP7-PEOPLE-2012-ITN, grant number 316758); ENGAGE,- European Network for Genetic and Genomic Epidemiology, (FP7-HEALTH-F4-2007, grant number 201413); the Swedish Research Council (A-C.S., grant number E0226301, C0524801); the Swedish Cancer Society (A-C. S., grant number 140581) the Swedish Childhood Cancer Foundation (A-C. S., grant number PR2014-0100), the Swedish Foundation for Strategic Research (A-C. S., grant number RBc08-008); the Erik, Karin and Gosta Selander's Stiftelse (E. B.).