Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference
Chloe CY Wong, Michael J Parsons, Kathryn J Lester, Joe Burrage, Thalia C Eley, Jonathan Mill, Emma L Dempster, Alice M Gregory
TWIN RESEARCH AND HUMAN GENETICS | CAMBRIDGE UNIV PRESS | Published : 2015
Diurnal preference is an individual's preference for daily activities and sleep timing and is strongly correlated with the underlying circadian clock and the sleep-wake cycle validating its use as an indirect circadian measure in humans. Recent research has implicated DNA methylation as a mechanism involved in the regulation of the circadian clock system in humans and other mammals. In order to evaluate the extent of epigenetic differences associated with diurnal preference, we examined genome-wide patterns of DNA methylation in DNA from monozygotic (MZ) twin-pairs discordant for diurnal preference. MZ twins were selected from a longitudinal twin study designed to investigate the interplay o..View full abstract
Awarded by Economic and Social Research Council
Awarded by Institute of Social Psychiatry
Awarded by Medical Research Council
This work was supported by a grant awarded by the Psychiatric Research Trust (to TCE, JM, and ELD). The G1219 Study collection wave 4 was supported by the Economic and Social Research Council (Grant No. RES-000-22-2206) and the Institute of Social Psychiatry (Grant No. 06/07-11) to AMG. Samples' DNA extraction was supported by a Goldsmiths Early Career Award to AMG. This study presents independent research part funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. We thank the families for their participation as well as numerous staff members and students from the Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, London, and Goldsmiths, University of London. The authors report no biomedical financial interests or potential conflicts of interest.