Journal article

Influenza Virus Neuraminidase Structure and Functions

Julie L McAuley, Brad P Gilbertson, Sanja Trifkovic, Lorena E Brown, Jennifer L McKimm-Breschkin

FRONTIERS IN MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2019

Abstract

With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance..

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Grants

Awarded by Australian Government National Health and Medical Research Council


Funding Acknowledgements

This work was supported by the Australian Government National Health and Medical Research Council grant 1079924 and program grant 1071916.