Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

E Balland; W Chen; GT Dodd; G Conductier; R Coppari; T Tiganis; MA Cowley

Journal article

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

E Balland, W Chen, GT Dodd, G Conductier, R Coppari, T Tiganis, MA Cowley

Cell Reports | CELL PRESS | Published : 2019

DOI: 10.1016/j.celrep.2018.12.061

Abstract

Balland et al. identify a molecular link between obesity and type 2 diabetes by demonstrating that, in obesity, leptin signaling in the CNS impairs the regulation of hepatic glucose production, leading to hyperglycemia.

University of Melbourne Researchers

Garron Dodd Author

Tony Tiganis Author

Grants

Awarded by Fondation pour la recherche juridique

Funding Acknowledgements

This research was supported by a postdoctoral fellowship to E.B. from Fondation pour la Recherche Medicale (FRM SPE20140129012), Diabetes Australia grant to E.B. and M.A.C. (DART Grant 2016), NHMRC fellowships 1079422 to M.A.C. and 1103037 to T.T., and NHMRC grant 1100240 to M.A.C. and T.T. and grants 1065641 and 1103193 to M.A.C.