Journal article

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

Garron T Dodd, Robert S Lee-Young, Jens C Bruening, Tony Tiganis

Diabetes | AMER DIABETES ASSOC | Published : 2018


Insulin regulates glucose metabolism by eliciting effects on peripheral tissues as well as the brain. Insulin receptor (IR) signaling inhibits AgRP-expressing neurons in the hypothalamus to contribute to the suppression of hepatic glucose production (HGP) by insulin, whereas AgRP neuronal activation attenuates brown adipose tissue (BAT) glucose uptake. The tyrosine phosphatase TCPTP suppresses IR signaling in AgRP neurons. Hypothalamic TCPTP is induced by fasting and degraded after feeding. Here we assessed the influence of TCPTP in AgRP neurons in the control of glucose metabolism. TCPTP deletion in AgRP neurons (Agrp-Cre;Ptpn2fl/fl ) enhanced insulin sensitivity, as assessed by the increas..

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University of Melbourne Researchers


Awarded by Diabetes Australia Research Trust

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by the Diabetes Australia Research Trust (Y16G-DODG to G.T.D.) and by the National Health and Medical Research Council of Australia (APP1100240 to T.T.). T.T. is a National Health and Medical Research Council Principal Research Fellow.