Journal article

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

Garron T Dodd, Zane B Andrews, Stephanie E Simonds, Natalie J Michael, Michael DeVeer, Jens C Bruening, David Spanswick, Michael A Cowley, Tony Tiganis

CELL METABOLISM | CELL PRESS | Published : 2017

Abstract

Beige adipocytes can interconvert between white and brown-like states and switch between energy storage versus expenditure. Here we report that beige adipocyte plasticity is important for feeding-associated changes in energy expenditure and is coordinated by the hypothalamus and the phosphatase TCPTP. A fasting-induced and glucocorticoid-mediated induction of TCPTP, inhibited insulin signaling in AgRP/NPY neurons, repressed the browning of white fat and decreased energy expenditure. Conversely feeding reduced hypothalamic TCPTP, to increase AgRP/NPY neuronal insulin signaling, white adipose tissue browning and energy expenditure. The feeding-induced repression of hypothalamic TCPTP was defec..

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