CENTRAL CANNABINOID SIGNALING MEDIATING FOOD INTAKE: A PHARMACOLOGICAL-CHALLENGE MAGNETIC RESONANCE IMAGING AND FUNCTIONAL HISTOLOGY STUDY IN RAT
GT Dodd, JA Stark, S Mckie, SR Williams, SM Luckman
NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009
Endocannabinoids have a variety of effects by acting through cannabinoid 1 (CB1) receptors located throughout the brain. However, since CB1 receptors are located presynaptically, and because the strength of downstream coupling varies with brain region, expression studies alone do not provide a firm basis for interpreting sites of action. Likewise, to date most functional studies have used high doses of drugs, which can bias results toward non-relevant adverse effects, and which mask more behaviourally-relevant actions. Here we use a low, orexigenic dose of the full CB1 agonist, CP55940, to map responsive brain regions using the complementary techniques of pharmacological-challenge functional..View full abstract
Awarded by Biotechnology and Biological Sciences Research Council
The authors wish to thank Ms. Karen Davies for providing technical assistance for maintenance of the MRI magnet and console. This work was supported by a Biotechnology and Bioscience Research Council grant; G. T. D. was supported by an Integrative Mammalian Physiology priority postgraduate studentship.