Journal article

CENTRAL CANNABINOID SIGNALING MEDIATING FOOD INTAKE: A PHARMACOLOGICAL-CHALLENGE MAGNETIC RESONANCE IMAGING AND FUNCTIONAL HISTOLOGY STUDY IN RAT

GT Dodd, JA Stark, S Mckie, SR Williams, SM Luckman

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009

Abstract

Endocannabinoids have a variety of effects by acting through cannabinoid 1 (CB1) receptors located throughout the brain. However, since CB1 receptors are located presynaptically, and because the strength of downstream coupling varies with brain region, expression studies alone do not provide a firm basis for interpreting sites of action. Likewise, to date most functional studies have used high doses of drugs, which can bias results toward non-relevant adverse effects, and which mask more behaviourally-relevant actions. Here we use a low, orexigenic dose of the full CB1 agonist, CP55940, to map responsive brain regions using the complementary techniques of pharmacological-challenge functional..

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University of Melbourne Researchers