Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells
Xi Zen Yap, Rachel J Lundie, Gaoqian Feng, Joanne Pooley, James G Beeson, Meredith O'Keeffe
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2019
Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and maintained, and how vaccine responses may be impacted by malaria infection or exposure. This study investigates the response of dendritic cells to two different life stages of the malaria parasite, parasitized red blood cells and merozoites, using a murine model. We demonstrate that the dendritic cell responses to merozoites are robust whereas dendritic cell activation, particu..View full abstract
Funding was provided by NHMRC (Senior Research Fellowships to JGB and MOK; Early Career Fellowship to RJL; Project grant to MOK). Burnet Institute was supported by the NHMRC Independent Research Institutes Support Scheme and a Victorian State Government Operational Infrastructure Grant. JB and GF are members of the Australian Centre for Research Excellence in Malaria Elimination (ACREME), funded by the NHMRC.