Discovery of N-Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel Na(V)1.2-Subtype-Selective Inhibitors
Phillip L van der Peet, Saman Sandanayake, Bevyn Jarrott, Spencer J Williams
ChemMedChem | WILEY-V C H VERLAG GMBH | Published : 2019
We are grateful to the National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP) for invivo mouse studies of the antiseizure properties of compound <BOLD>2</BOLD>. We thank FastForward (USA) for project funding, and invaluable advice from Dr. John Lowe (JL3Pharma, Stonington, CT, USA).