Journal article
Type I interferon induces CXCL13 to support ectopic germinal center formation
AE Denton, S Innocentin, EJ Carr, BM Bradford, F Lafouresse, NA Mabbott, U Mörbe, B Ludewig, JR Groom, KL Good-Jacobson, MA Linterman
Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2019
DOI: 10.1084/jem.20181216
Abstract
Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection, this response can be beneficial for the host: influenza A virus infection–induced pulmonary ectopic germinal centers give rise to more broadly cross-reactive antibody responses, thereby generating cross-strain protection. However, despite the ubiquity of ectopic lymphoid structures and their role in both health and disease, little is known about the mechanisms by which inflammation is able to convert a peripheral tissue into one that resembles a secondary lymphoid organ. Here, we show that type I IFN produced after viral infection can ..
View full abstractGrants
Awarded by Babraham Institute
Funding Acknowledgements
This study was supported by the Biotechnology and Biological Sciences Research Council (grants BBS/E/B/000C0407 and BBS/E/B/000C0427), Core Capability Grant funding to the Babraham Institute Facilities, and the National Health and Medical Research Council (project grant 1137989 to J.R. Groom and K.L. Good-Jacobson and project grant 1057707 to K.L. Good-Jacobson). A.E. Denton is supported by the Biotechnology and Biological Sciences Research Council (Future Leader Fellowship BB/N011740/1). Development of the Cxcr5<SUP>fl/fl</SUP> (strain Cxcr5<SUP>tm1.Namt</SUP>) was supported by the Biotechnology and Biological Sciences Research Council (grants BB/F019726/1 and BBS/E/D/20002174 to N.A. Mabbott and B.M. Bradford). F. Lafouresse is supported by a Walter and Eliza Hall Centenary Fellowship. J.R. Groom is supported by the Australian Research Council (Future Fellowship FT130100708). K.L. Good-Jacobson is supported by the National Health and Medical Research Council (Career Development Fellowship 1108066).