A Prospective, Multicenter Study of Involved-Field Radiation Therapy With Autologous Stem Cell Transplantation for Patients With Hodgkin Lymphoma and Aggressive Non-Hodgkin Lymphoma (ALLG HDNHL04/TROG 03.03)
Andrew Wirth, H Miles Prince, Daniel Roos, John Gibson, Peter O'Brien, Diana Zannino, Bereha Khodr, Janey M Stone, Sidney Davis, Mark Hertzberg
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | ELSEVIER SCIENCE INC | Published : 2019
PURPOSE: The role of involved-field radiation therapy (IFRT) with autologous stem cell transplantation (ASCT) for lymphomas remains uncertain. METHODS AND MATERIALS: In this prospective, multicenter study, patients undergoing ASCT for relapsed/refractory lymphoma received peritransplant IFRT to disease sites identified at study registration (SR) (before salvage chemotherapy [SC]). Radiation dose was adapted to SC response. Survival, relapse rates/pattern, toxicity, and prognostic factors were evaluated. RESULTS: Forty-five patients were enrolled (23 with Hodgkin lymphoma, 22 with aggressive non-Hodgkin lymphoma). Three-year overall survival and cumulative incidence of posttransplant progress..View full abstract
This work was supported by a grant from Amgen, which had no involvement in the study design, collection, analysis and interpretation of data, the writing of the report, or in the decision to submit the article for publication. The trial was co-sponsored in Australia by the cooperative trial groups Australasian Leukaemia and Lymphoma Group (ALLG), and Trans-Tasman Radiation Oncology Group (TROG) The authors thank Sidney Davis, Daniel Roos and Peter O'Brien for performing the quality assurance review, and John Reynolds for statistical advice in the early stages of the trial.