Journal article

TERT gene: its function and dysregulation in cancer

Andrew J Colebatch, Alexander Dobrovic, Wendy A Cooper

Journal of Clinical Pathology | BMJ PUBLISHING GROUP | Published : 2019


In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.

University of Melbourne Researchers