Parathyroid hormone-related protein

Abstract

This chapter reviews the physiology of parathyroid hormone-related protein (PTHrP) and its role in pathophysiology apart from hypercalcemia. The physiological significance of the various PTHrP transcripts remains unclear, although some cells preferentially transcribe specific 3' coding variants. PTHrP normally serves local autocrine, paracrine, or intracrine functions but, in patients with humoral hypercalcemia of malignancy (HHM), PTHrP circulates and mimics the systemic actions of parathyroid hormone (PTH). Most studies in vitro suggest that PTHrP and PTH are equipotent at triggering identical signaling events and biological effects downstream of the Type 1 PTH/PTHrP receptor (PTH1R). Mid-..