The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development
Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino
Placenta | W B SAUNDERS CO LTD | Published : 2019
Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and a complete lack of therapeutic options. We define placenta-enriched molecules as those that are highly expressed in the placenta relative to all other human tissues. Many exist including mRNAs, miRNAs and proteins. It is now well established that placenta-enriched mRNAs are found within the maternal circulation and are cleared rapidly after birth. Similarly, distinct clusters of miRNAs that are placenta-enriched have been identified and are measurable within the circulation. However, perhaps the most established potential diagnostics thus far are circulating plac..View full abstract
Awarded by (National Health and Medical Research Council of Australia Fellowships)
S Tong (#1136418), T.J. Kaitu'u-Lino (#1159261), N.J. Hannan (#1146128) were supported by National Health and Medical Research Council of Australia Fellowships).