Journal article
The association between weight at birth and breast cancer risk revisited using Mendelian randomisation
SP Kar, IL Andrulis, H Brenner, S Burgess, J Chang-Claude, D Considine, T Dörk, DGR Evans, M Gago-Domínguez, GG Giles, M Hartman, D Huo, R Kaaks, J Li, A Lophatananon, S Margolin, RL Milne, KR Muir, H Olsson, K Punie Show all
European Journal of Epidemiology | SPRINGER | Published : 2019
Abstract
Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weight..
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Funding Acknowledgements
Funding was provided by Cancer Research UK (grant number C490/A16561 to Paul D. P. Pharoah).