Journal article

Role of IgG3 in Infectious Diseases

Timon Damelang, Stephen J Rogerson, Stephen J Kent, Amy W Chung

Trends in Immunology | ELSEVIER SCI LTD | Published : 2019

Abstract

IgG3 comprises only a minor fraction of IgG and has remained relatively understudied until recent years. Key physiochemical characteristics of IgG3 include an elongated hinge region, greater molecular flexibility, extensive polymorphisms, and additional glycosylation sites not present on other IgG subclasses. These characteristics make IgG3 a uniquely potent immunoglobulin, with the potential for triggering effector functions including complement activation, antibody (Ab)-mediated phagocytosis, or Ab-mediated cellular cytotoxicity (ADCC). Recent studies underscore the importance of IgG3 effector functions against a range of pathogens and have provided approaches to overcome IgG3-associated l..

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Grants

Funding Acknowledgements

We thank Milla McClean and Ester Lopez for their assistance revising this manuscript. This work was supported by funding from the University of Melbourne (T.D.), National Health and Medical Research Council of Australia (NHMRC) (S.J.R., S.J. K., A.W.C.), by the Australian Centre for Research Excellence in Malaria Elimination (ACREME) (S.J.R.) and the American Foundation for AIDS Research (amfAR) Mathilde Krim Fellowship (A.W.C.).